A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/675 (2006.01) A61K 31/66 (2006.01)
Patent
CA 2120538
The present invention relates to the use of bisphosphonic acid derivative of formula (I): (see fig. I) in which: - R1 is a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono-C1-4-alkylamino or a di-C1-C4-alkylamino, and - R2 is a halogen atom or a linear alkyl containing from 1 to 5 carbon atoms which is unsubstituted or substituted by a group selected from a chlorine atom, a hydroxyl, an amino, a mono-C1-C4-alkylamino, a di-C1-C4-alkylamino and a C3-C7-cycloalkylamino, or R2 is a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridylmethyl, a 1- pyridyl-1-hydroxymethyl, an imidazolylmethyl or a thiomorpholin-4-yl; and their salts with pharmaceutically acceptable mineral or organic acids, for promoting bone repair in human or veterinary medicine. It also relates to pharmaceutical compositions for promoting bone repair which comprise derivatives of formula (I).
La présente invention porte sur l'emploi d'un dérivé d'acide bisphosphonique de formule (I) (voir fig. I), où : R1 est un atome d'hydrogène, un atome d'halogène, un hydroxyle, un amino, un monoalkyl-C1-4-amino ou un dialkyl-C1-C4-amino; R2 est un atome d'halogène ou un alkyle linéaire renfermant de 1 à 5 atomes de carbone, avec ou sans substitution par un groupe choisi parmi un atome de chlore, un hydroxyle, un amino, un monoalkyl-C1-C4-amino, un dialkyl-C1-C4-amino et un cycloalkyl-C3-C7-amino, ou R2 est un groupe phénoxy, phényle, thiol, phénylthio, chlorophénylthio, pyridyle, pyridylméthyle, 1-pyridyl-1-hydroxyméthyle, imidazolylméthyle ou thiomorpholin-4-yle. L'invention porte également sur leurs sels avec des acides minéraux ou organiques pharmacocompatibles, utiles pour activer la restauration osseuse ou dans les applications de médecine vétérinaire. L'invention porte enfin sur des compositions pharmaceutiques à base des dérivés de formule (I), permettant d'activer la restauration osseuse.
Barbier Alain
Lacheretz Frederic
Sanofi-Aventis
Sim & Mcburney
LandOfFree
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