A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/04 (2006.01) A61P 1/00 (2006.01) A61P 7/00 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2590804
The invention concerns the use of a bombesin/gastrin releasing peptide antagonist in the preparation of a pharmaceutical composition for the treatment of inflammatory and immune-mediated inflammatory conditions, in particular sepsis, acute lung injury and rheumatoid arthritis as well as for the treatment or prophylaxis of brain disorders, pref~erably bipolar disorder, and in particular the different forms and/or subforms of bipolar disorder, such as mania, acute mania, severe mania, hypomania, depression, moder~ate depression, dysthymia, severe depression, episodes of mania and/or depression, psychosis/psychotic symptoms (e.g. hallucinations, delusions), mixed bipolar state, bipolar I disorder, bipolar II disorder and/or rapid-cycling bipolar disorder. In particular, specific nonapeptides with antagonist properties against bombesin or bombesin-like peptides, such as the gastrin releasing peptide, may be used in the treatment of in~flammatory and immune-mediated inflammatory conditions as well as brain disorders.
L'invention concerne l'utilisation d'un antagoniste de peptides libérant de la bombésine/gastrine dans la préparation d'une composition pharmaceutique destinée au traitement d'états inflammatoires et inflammatoires à médiation immune, notamment la sepsie, une blessure grave des poumons et l'arthrite rhumatoïde, ainsi que pour le traitement ou la prophylaxie de troubles cérébraux, de préférence, de trouble bipolaire, et notamment les diverses formes et/ou sous-formes de trouble bipolaire, tels que la manie, la manie aiguë, la manie sévère, l'hypomanie, la dépression, la dépression modérée, la dysthymie, la dépression sévère, des épisodes de manie et/ou de dépression, la psychose/des symptômes psychotiques (par exemple, des hallucinations, des illusions sensorielles), un état bipolaire mixte, le trouble bipolaire I, II et/ou le trouble bipolaire à cycles rapides. Plus précisément, des nanopeptides spécifiques possédant des propriétés antagonistes contre la bombésine ou des peptides de type bombésine, tels que le peptide de libération de la gastrine, peuvent être utilisés dans le traitement de troubles inflammatoires et inflammatoires à médiation immune, ainsi que de troubles cérébraux.
Dal Pizzol Felipe
Kapczinski Flavio
Quevedo Joao Luciano
Roesler Rafael
Schwartsmann Gilberto
Bexar Global Inc.
Marks & Clerk
Zentaris Gmbh
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