Use of bone marrow cells for long term culture of pancreatic...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/071 (2010.01) A61K 35/28 (2006.01) A61K 35/39 (2006.01) A61P 3/10 (2006.01) C12N 5/02 (2006.01) C12N 5/0789 (2010.01)

Patent

CA 2670289

Bone marrow cells have been demonstrated to be useful in the maintenance of pancreatic islet .beta. cell viability, structure, and/or function in culture for a sustained period. Bone marrow cells were also found to promote .beta. cell growth while reducing inflammatory cytokine release and reduce apoptosis. Moreover, islet cells co-cultured with bone marrow cells were shown to retain insulin response function and to function in an islet cell transplant in a mouse model of diabetes to restore normal insulin secretion. Cord blood cells and isolated peripheral CD34+ blood cells were unable to support .beta. islet cell growth or increase survival.

Selon cette invention, les cellules de la moelle osseuse s'avèrent être utiles pour maintenir en culture la viabilité, la structure et/ou la fonction des cellules .beta. des îlots pancréatiques sur une durée prolongée. Les cellules de la moelle osseuse s'avèrent également favoriser la croissance des cellules .beta. tout en réduisant la libération des cytokines inflammatoires, et réduire l'apotose. De plus, il apparaît que les cellules des îlots co-cultivées avec des cellules de la moelle osseuse retiennent la fonction de la réponse insulinaire et agissent dans une transplantation des cellules des lots dans un modèle du diabète de la souris pour rétablir la sécrétion normale de l'insuline. Les cellules du sang ombilical et les cellules isolées du sang périphérique CD34+ ont été incapables de soutenir la croissance des cellules .beta. des îlots ou d'accroître leur survie.

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