Use of bradykinin-b2 receptor antagonists for treating...

A - Human Necessities – 61 – K

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A61K 38/04 (2006.01) A61K 38/08 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2514152

Peptides that have a Bradykinin-antagonistic effect are suitable for the production of drugs for use in the prophylaxis and therapy of diseases whose progression is associated with an increased activity of matrix metalloproteinases. These diseases include degenerative articular diseases, for example osteoarthrosis, spondylosis and chondroporosis after joint trauma or prolonged joint immobilization after meniscus or patella injuries or ruptures of a ligament.

Les peptides à effet antagoniste de la bradykinine sont adaptés à la préparation de médicaments pour le traitement prophylactique et thérapeutique de maladies dont le développement est en partie dû à l'activité accrue de métalloprotéinases matricielles. Font partie de ces maladies les maladies articulaires dégénératives, par exemple l'ostéoarthrose et la spondylose, l'atrophie du cartilage suite à une lésion articulaire ou à une position de repos prolongée de l'articulation après lésion d'un ménisque ou d'une rotule ou bien des déchirures ligamentaires.

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