Use of carbamazepine derivatives for the treatment of...

Details Use of carbamazepine derivatives for the treatment of... Use of carbamazepine derivatives for the treatment of...

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61P 25/14 (2006.01)

Patent

CA 2521371

The present invention relates to the use of a compound of formula (I) wherein (a) R1 and R2 together form an oxy group or (b) R1 is hydrogen and R2 is hydroxy or acetoxy, or a pharmaceutically acceptable salt thereof, for the manufacture of a pharmaceutical composition for the treatment of agitation, in particular behavioral agitation, especially in dementia patients; a method for the treatment of agitation; pharmaceutical compositions comprising a compound of formula I; a combination comprising (a) a compound of formula I and (b) at least one compound selected from the group consisting of nootropic plant extracts, calcium antagonists, cholinesterase inhibitors, dihydroergotoxin, nicergoline, piracetame, purine derivates, pyritinol, vincamine and vinpocetine; and a commercial package including such combination.

L'invention concerne l'utilisation d'un composé de formule I dans laquelle : (a) R¿1? et R¿2? forment ensemble un groupe oxy, ou (b) R¿1? représente hydrogène et R¿2? représente hydroxy ou acétoxy, ou un sel pharmaceutiquement acceptable de celui-ci, dans la fabrication d'une composition pharmaceutique servant à traiter l'agitation, en particulier l'agitation comportementale, surtout chez les patients atteints de démence. L'invention concerne également une méthode de traitement de l'agitation ; des compositions pharmaceutiques contenant un composé de formule I ; une combinaison contenant : (a) un composé de formule I, et (b) au moins un composé choisi dans le groupe constitué par des extraits végétaux nootropiques, des antagonistes de calcium, des inhibiteurs de la cholinestérase, la dihydroergotoxine, la nicergoline, le piracétame, des dérivés de purine, le pyritinol, la vincamine et la vinpocétine ; ainsi qu'un emballage commercial contenant ladite combinaison.

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