A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/59 (2006.01) A61K 31/593 (2006.01) A61P 3/02 (2006.01) A61P 3/14 (2006.01)
Patent
CA 2480125
It has been discovered that the 2-carbon-modified derivatives of 1.alpha.,25- dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bone is required. Thus, these compounds can be used either systemically or locally to stimulate the growth of bone transplants, to increase the rate of fracture healing and thereby reduce the time required for the healing of fractures, the stimulation of bone growth when required for replacement surgery, and also for the growth of bone to implants or other devices required to maintain the skeleton or teeth in the proper positions.
L'information concerne des dérivés de 1?,25-dihydroxyvitamine D¿3? portant une modification sur le carbone 2 stimulant spécifiquement les ostéoblastes à former de l'os nouveau. La capacité d'analogues de vitamine D modifiée sur le carbone 2 à stimuler la formation d'os nouveau suggère que ces composés peuvent être utilisés là où la synthèse d'os nouveau est requise. Ainsi, ces composés peuvent être utilisés de façon systémique ou locale afin de stimuler la croissance de transplants osseux de manière à augmenter le taux de consolidation de fracture et ainsi réduire le temps requis pour cette consolidation, de stimuler la croissance osseuse nécessaire en chirurgie de remplacement, ainsi que la croissance d'implants osseux ou d'autres dispositifs nécessaires au maintien, dans des positions correctes, du squelette ou de dents.
Deluca Hector F.
Pike J. Wesley
Shevde Nirupama K.
Borden Ladner Gervais Llp
Wisconsin Alumni Research Foundation
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