Use of carboxypeptidase g for combating antifolate toxicity

Details Use of carboxypeptidase g for combating antifolate toxicity Use of carboxypeptidase g for combating antifolate toxicity

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 38/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2557610

A method of combating toxicity caused by an antifolate compound of Formula: (I), in an individual who has been administered the compound. The method comprises administering an enzyme that has carboxypeptidase G activity to the individual. A method of cleaving a compound comprising a structural fragment of Formula: (VIII), the method comprising contacting the compound comprising the structural fragment of Formula: (VIII) with an enzyme that has carboxypeptidase G activity.

L'invention concerne une méthode visant à réduire la toxicité causée par l'administration d'un composé antifolique de formule I à un individu. Ce procédé consiste à administrer à cet individu une enzyme présentant une activité carboxypeptidase G. L'invention concerne également un procédé de clivage d'un composé contenant un fragment structurel de formule VIII, ce procédé consistant à mettre en contact le composé contenant le fragment structurel de formule VIII avec une enzyme présentant une activité carboxypeptidase G.

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