Use of cationic dextran derivatives for protecting...

A - Human Necessities – 61 – K

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A61K 31/721 (2006.01) C08B 37/02 (2006.01)

Patent

CA 2443052

The present invention discloses the use of cationic dextran derivatives provided with substituents having positively charged side groups as protective agents for dosage limiting organs in systemic treatment of diseases including cancer. The cationic dextran derivatives are particularly useful nephroprotective agents for a subject receiving systemic treatment with cytostatic pharmaceuticals, compounds carrying cytostatic pharmaceuticals, radionuclides or compounds carrying radionuclides against renal damage. The cationic dextran derivatives not only protect the dose-limiting organs but are better tolerated and have less side effects than conventionally used protective agents.

La présente invention concerne l'utilisation de dérivés cationiques du dextrane avec des substituants comprenant des groupes latéraux chargés positivement comme agents de protection destinés aux organes à limitation de dose dans le traitement systémique de maladies telles que le cancer. Ces dérivés cationiques du dextrane sont particulièrement utiles comme agents nephroprotecteurs chez un sujet soumis à un traitement systémique avec des agents pharmaceutiques cytostatiques, des composés renfermant des agents pharmaceutiques cytostatiques, des radionucléides ou des composés renfermant des radionucléides contre les lésions rénales. Ces dérivés cationiques du dextrane ne protègent pas uniquement les organes à limitation de dose, mais sont également mieux tolérés et entraînent moins d'effets secondaires que les agents de protection couramment utilisés.

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