C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 1/04 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2401249
Use of CD25 binding molecule which comprises at least one antigen binding site comprising at least one domain which comprises in sequence, the hypervariable regions CDR1, CDR2 and CDR3; said CDR1 having the amino acid sequence Arg-Tyr- Trp-Met-His, said CDR2 having the amino acid sequence Ala-Ile-Tyr-Pro-Gly-Asn- Ser-Asp-Thr-Ser-Tyr-Asn-Gln-Lys-Phe-Glu-Gly, and said CDR3 having the amino acid sequence Asp-Tyr-Gly-Tyr-Tyr-Phe-Asp-Phe, in the treatment of inflammatory disease of the gastro-intestinal tract.
L'invention concerne l'utilisation d'une molécule se liant à CD25 dans le traitement de maladies inflammatoires du tractus gastro-intestinal. Cette molécule comprend au moins un site de liaison à l'antigène contenant au moins un domaine qui comporte séquentiellement les régions hypervariables CDR1, CDR2 et CDR3 ; la région CDR1 comporte la séquence d'acides aminés Arg-Tyr-Trp-Met-His, la région CDR2 comporte la séquence d'acides aminés Ala-Ile-Tyr-Pro-Gly-Asn-Ser-Asp-Thr-Ser-Tyr-Asn-Gln-Lys-Phe-Glu-Gly, et la région CDR3 comporte la séquence d'acides aminés Asp-Tyr-Gly-Tyr-Tyr-Phe-Asp-Phe.
Adam Hansjoerg
Farber Lothar
Fetherstonhaugh & Co.
Novartis Ag
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