C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) C07K 16/28 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2357035
The invention relates to methods for altering and enhancing the immune response toward an antigen. More specifically, the present invention relates to methods of using CD40 engagement on T cells to induce T cell receptor gene rearrangement and enhance T cell affinity for a particular antigen. The invention also relates to methods for promoting developmental maturation of an immature cell of the T cell lineage.
La présente invention concerne des procédés de modification et d'augmentation de la réponse immunitaire envers un antigène. Plus particulièrement, cette invention concerne des procédés d'utilisation de l'accouplement de CD40 avec des lymphocytes T pour induire le réarrangement du gène récepteur des lymphocytes T, et augmenter l'affinité des lymphocytes T vis-à-vis d'un antigène particulier. Par ailleurs, cette invention concerne des procédés favorisant la maturation du développement d'une cellule immature de la lignée de lymphocytes T.
Newell Evan
Newell Martha K.
Wagner David
Smart & Biggar
University Of Vermont And State Agricultural College
LandOfFree
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