Use of cell lines to produce active therapeutic proteins

Details Use of cell lines to produce active therapeutic proteins Use of cell lines to produce active therapeutic proteins

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 38/19 (2006.01) C12N 15/00 (2006.01) C12N 15/86 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2541380

This invention relates to the production of proteins, including therapeutic plasma proteins, by virally-immortalized hepatocyte cell lines and by other eukaryotic cells, as well as to the use of such proteins for screening and therapy, as well as to nucleic acids, vectors, and transformed or transfected cells that carry the genetic information for proteins.

L'invention concerne la production de protéines, notamment de protéines plasmatiques thérapeutiques, au moyen de lignées de cellules hépatiques viralement immortalisées et au moyen d'autres cellules eucaryotes. L'invention concerne également l'utilisation de telles protéines à des fins de criblage et de thérapie, ainsi que des acides nucléiques, des vecteurs et des cellules transformées ou transfectées qui portent les informations génétiques pour des protéines.

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