Use of cell-permeable peptide inhibitors of the jnk signal...

A - Human Necessities – 61 – K

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A61K 38/01 (2006.01) A61K 38/03 (2006.01) A61K 38/04 (2006.01) A61P 1/04 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2725547

The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor sequences, chimeric peptides, or of nucleic acids encoding same as well as pharmaceutical compositions containing same, for the treatment of non- chronic or chronic inflammatory digestive dis-eases, such as colitis, including e.g. Ulcerative colitis, Crohn's disease, diversion colitis, ischemic colitis, infectious colitis, fulmi-nant colitis, chemical colitis, microscopic colitis, lymphocytic colitis, and atypical colitis, etc..

La présente invention porte sur l'utilisation d'inhibiteurs de protéine kinase et, plus spécifiquement, sur l'utilisation d'inhibiteurs de la protéine kinase c-Jun, une kinase à extrémité amino-terminale, de séquences d'inhibiteurs de JNK, de peptides chimériques ou d'acides nucléiques codant pour ceux-ci, ainsi que sur des compositions pharmaceutiques contenant ceux-ci, pour le traitement de maladies digestives inflammatoires non chroniques ou chroniques, telles que la colite, comprenant, par exemple, la colite ulcérative, la maladie de Crohn, la colite de diversion, la colite ischémique, la colite infectieuse, la colite fulminante, la colite chimique, la colite microscopique, la colite lymphocytaire et la colite atypique, etc.

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