A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/737 (2006.01) A61K 31/721 (2006.01) A61P 11/12 (2006.01)
Patent
CA 2382259
The present invention is for a charged dextran, preferably dextran sulfate, as an improved mucoactive agent which can be used to improve viscoelasticity and clearance of respiratory tract mucus. The charged dextran can be used in the treatment of animals with impaired mucus clearance, mucus retention and/or mucus hypersecretion, such as cystic fibrosis, chronic bronchitis, bronchiectasis, bronchiolitis and bronchial asthma. Related methods of treatment and pharmaceutical compositions, particularly aerosolized dextran sulfate compositions are encompassed within the scope of the invention.
Cette invention a trait à du dextrane chargé, de préférence du dextran-sulfate, en tant qu'agent mucoactif amélioré, pouvant être utilisé pour augmenter la viscoélasticité et la clairance du mucus des voies respiratoires. On peut utiliser ce dextrane chargé pour traiter des animaux présentant une déficience de la clairance du mucus ou souffrant de rétention du mucus et/ou d'hypersécrétion de mucus, notamment en cas de mucoviscidose, de bronchite chronique, de bronchectasie, de bronchiolite et d'asthme. L'invention concerne également des méthodes connexes de traitement et des compositions pharmaceutiques, notamment des compositions à base de dextran-sulfate en aérosols.
Bereskin & Parr
Governors Of The University Of Alberta
LandOfFree
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