Use of charged phospholipids to reduce nanoparticle aggregation

Details Use of charged phospholipids to reduce nanoparticle aggregation Use of charged phospholipids to reduce nanoparticle aggregation

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 9/14 (2006.01) A61K 47/48 (2006.01) A61K 49/04 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2102267

- 0 - ABSTRACT This invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred non-ionic surfactant surface modifier is a poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoyl phosphatidyl glycerol. This invention further discloses a method of making nanoparticles having a non- ionic surfactant as a surface modifier adsorbed on the surface and a charged phospholipid as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

Affiliated with

Also associated with

Rating

Use of charged phospholipids to reduce nanoparticle aggregation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of charged phospholipids to reduce nanoparticle aggregation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of charged phospholipids to reduce nanoparticle aggregation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2047005