Use of charged phospholipids to reduce nanoparticle aggregation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/51 (2006.01) A61K 9/14 (2006.01) A61K 47/48 (2006.01) A61K 49/04 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2102267

- 0 - ABSTRACT This invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred non-ionic surfactant surface modifier is a poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoyl phosphatidyl glycerol. This invention further discloses a method of making nanoparticles having a non- ionic surfactant as a surface modifier adsorbed on the surface and a charged phospholipid as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

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