Use of chk1 inhibitors to control cell proliferation

Details Use of chk1 inhibitors to control cell proliferation Use of chk1 inhibitors to control cell proliferation

A - Human Necessities

61

K

A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 31/7048 (2006.01) A61K 31/7068 (2006.01) A61K 33/24 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2539320

The present invention relates to improved methods for inhibiting aberrant cell proliferation involving the scheduling of administration of Chk1 activators (e.g., chemotherapeutic agents) and Chk1 inhibitors. At least one Chk1 activator is administered at a dose and for a time sufficient to induce substantial synchronization of cell cycle arrest in proliferating cells. Upon achieving substantial phase synchronization, at least one Chk1 inhibitor is administered to abrogate the cell cycle arrest and induce therapeutic cell death. The invention is useful with any Chk1 activator and any Chk1 inhibitor, and finds application in treating or preventing cancerous and non-cancerous aberrant cell proliferation.

L'invention concerne des procédés améliorés permettant d'inhiber la prolifération cellulaire aberrante impliquant la planification d'administration d'activateurs de la Chk1 (par exemple, des agents chimiothérapeutiques) et des inhibiteurs de la Chk1. Au moins un activateur de la Chk1 est administré à une dose et une durée suffisantes pour induire une synchronisation sensible d'interruption du cycle cellulaire dans des cellules de prolifération. Après obtention de la synchronisation sensible de phase, au moins un inhibiteur de la Chk1 est administré afin de supprimer l'interruption du cycle cellulaire et d'induire la mort cellulaire thérapeutique. L'invention peut être mise en oeuvre avec tout activateur de la Chk1 et tout inhibiteur de la Chk1, et peut être mise en application dans le traitement ou la prévention de la prolifération cellulaire aberrante cancéreuse et non cancéreuse.

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