Use of chroman derivatives for the treatment of depressive...

Details Use of chroman derivatives for the treatment of depressive... Use of chroman derivatives for the treatment of depressive...

A - Human Necessities

61

K

167/208

A61K 31/44 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01)

Patent

CA 2003696

ABSTRACT OF THE DISCLOSURE A method of treatment of depressive states which comprises administering in mammals in need thereof an effective amount of a compound Image (I) - R1 represents hydrogen, a halogen atom, a cyano group, a nitro group, an acetyl group or a trifluoromethyl group; - R2 represents a hydroxyl group, in which case R3 represents a hydrogen atom, or R2 and R3 taken together represent an additional bond between the carbon atoms by which they are carried; and - R4 represents a 2-oxopyrrolidin-1-yl or 2-oxopiperid- 1-yl group or a heterocyclic group selected from 1H- pyrid-2-on-1-yl, 1H-pyridazin-6-on-1-yl, 1H-pyrimidin- 2-on-1-yl, 1H-pyrimidin-6-on-1-yl, 1H-pyrazin-2-on-1 - yl and 1H-thiopyrid-2-on-1-yl groups which are unsubstituted or monosubstituted or disubstituted by a C1-C4 alkyl group, a halogen atom or a hydroxyl, nitro, amino or carboxyl group and the pharmaceutically acceptable salts thereof.

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