A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/558 (2006.01) A61K 31/17 (2006.01) A61K 31/20 (2006.01) A61K 31/23 (2006.01) A61K 31/7105 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2560878
It has now been discovered that inhibitors of soluble epoxide hydrolase ("sEH") are useful in reducing the severity of or inhibiting the progression of obstructive pulmonary diseases, restrictive airway diseases, and asthma. Administering a cis-epoxyeicosantrienoic acid ("EET") in addition to the inhibitor is at least additive, and may be synergistic, in reducing or inhibiting these conditions and diseases, as measured by reduced numbers of neutrophils present in the lung. The inhibitor of sEH may be a nucleic acid, such as a small interfering RNA.
On a découvert que les inhibiteurs de l'hydrolase d'époxyde soluble ou "sHE" permettent de réduire la gravité ou de bloquer la progression des maladies pulmonaires obstructives, des maladies à restriction des voies respiratoires, et de l'asthme. L'administration d'un acide cis-époxyéïcosantriénoïque ou "EET" associé à l'inhibiteur présente un effet complémentaire, voire synergique, dans la réduction ou l'inhibition de ces états et maladies, comme en atteste la diminution du nombre mesuré de neutrophiles présents dans le poumon. L'inhibiteur du sHE peut être un acide nucléique tel qu'un petit ARN interférant.
Hammock Bruce D.
Ma Seung Jin
Pinkerton Kent E.
Smith Kevin R.
Watanabe Takaho
Borden Ladner Gervais Llp
The Regents Of The University Of California
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