A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2271781
The present invention refers to the use of hCNTF (human ciliary neurotrophic factor), mutants thereof or other molecules that activate the CNTF receptor, for the preparation of drugs for the treatment of obesity and associated diseases, for example hyperglycemia. Figure 1 shows the anti-obesity effect of hCNTF and leptin on body weight (left panels) and on food intake (right panels) in genetically obese mice and in mice with diet-induced obesity (DIO).
La présente invention concerne l'utilisation du hCNTF (facteur neurotrophique ciliaire humain), de certains de ses mutants, ou d'autres molécules qui activent le récepteur du CNTF, pour l'élaboration de médicaments destinés au traitement de l'obésité et de ses maladies associées telles que l'hyperglycémie. La Figure 1 illustre l'efficacité anti-obésité du hCNTF et l'efficacité de la leptine sur la masse corporelle (tableaux de gauche) et sur la ration alimentaire (tableaux de droite) chez des souris génétiquement obèses et sur des souris à obésité induite par le régime alimentaire (DIO).
Ciliberto Gennaro
Cortese Riccardo
Costa Patrizia
de Martis Anna
Di Marco Annalise
Fetherstonhaugh & Co.
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
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