Use of colesevelam in reducing serum glucose

Details Use of colesevelam in reducing serum glucose Use of colesevelam in reducing serum glucose

A - Human Necessities

61

K

A61K 31/785 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2444046

A method for treating hyperglycemia and/or reducing serum glucose levels in a patient that includes administering to the patient a therapeutically effective amount of an amine polymer is disclosed. In one embodiment, the amine polymer is aliphatic. Examples of polymers useful in an embodiment of the invention include sevelamer hydrogen chloride and colesevelam. The invention includes the use of amine polymers such as a cross-linked polymer characterized by a repeat unit having the formula: and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4. Also described is a use, for the manufacture of a medicament, of a polymer that lowers serum glucose.

L'invention concerne une méthode pour traiter l'hyperglycémie et/ou réduire le niveau de glucose dans le sérum d'un patient, consistant à administrer au patient une dose thérapeutiquement efficace d'un polymère amine. Dans un mode de réalisation, ce polymère amine est aliphatique. Dans un autre mode de réalisation, les exemples de polymères employés comprennent le chlorhydrate de sevelamer et le colesevelam. La méthode comprend l'utilisation de polymères amine tels qu'un polymère réticulé caractérisé par une unité de répétition de formule (1), ainsi que ses sels et ses copolymères, n étant un nombre entier positif et x étant zéro ou un nombre entier entre 1 et environ 4. La présente invention porte également sur la préparation d'un médicament comprenant un polymère qui diminue le glucose dans le sérum.

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