Use of compounds having ccr antagonism

A - Human Necessities – 61 – K

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A61K 31/445 (2006.01) A61K 31/351 (2006.01) A61K 31/4545 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 1/14 (2006.01) A61P 1/16 (2006.01) A61P 1/18 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 7/00 (2006.01) A61P 7/02 (2006.01) A61P 7/10 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/14 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 13/08 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2483253

It is intended to provide preventives/remedies for graft versus host disease and/or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis. The above object can be achieved by preventives/remedies for graft versus host disease and/or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis characterized by containing a specific compound having CCR (CC chemokine receptor) antagonism.

La présente invention concerne des médicaments prophylactiques ou thérapeutiques contre des affections opposant le greffon à l'hôte et/ou contre le rejet en cas de transplantation d'organe ou de moëlle osseuse, ainsi que contre la polyarthrite rhumatoïde, contre des affections autoimmunes ou allergiques, contre des lésions ischémiques des cellules cérébrales, contre l'infarctus du myocarde, contre la néphrite chronique et l'arthériosclérose. Ces médicaments sont caractérisés en ce qu'il contiennent un composé spécifique présentant un antagonisme contre les CCR (récepteurs des chimiokines CC).

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