A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/22 (2006.01)
Patent
CA 2488358
The present invention relates to peptides which are highly biologically and pharmacologically active as therapeutic drug for the treatment of diseases related to sarcoidosis. The peptides which can be used according to the invention for the treatment of said disease comprise at least one specific highly conservative amino acid residue sequence which seem to play an important role in connection with pulmonary and arteriolar hypertension events. It could be shown that the known naturally occurring peptides "vasoactive intestinal peptide (VIP)" and "pituitary adenylate cyclase- activating polypeptide (PACAP)", having these specific sequences are potent drugs which can be successfully used for treatment of sarcoidosis. Furthermore, the present invention discloses a method for the treatment patients suffering from sarcoidosis.
L'invention concerne des peptides présentant une activité biologique et pharmacologique élevée qui peuvent servir de médicament thérapeutique pour traiter des maladies liées à la sarcoïdose. Ces peptides qui peuvent être employés selon l'invention pour traiter ladite maladie, comprennent au moins une séquence spécifique très conservée de résidus d'acides aminés, qui semble jouer un rôle important dans les phénomènes d'hypertension artérielle pulmonaire. Il a été montré que les peptides d'origine naturelle connus, le peptide intestinal vasoactif (VIP) et le polypeptide activant l'adénylate cyclase pituitaire (PACAP), qui comportent ces séquences spécifiques, constituent des médicaments potentiels qui peuvent être utilisés de manière fructueuse pour traiter une sarcoïdose. Cette invention se rapporte en outre à un procédé permettant de traiter des patients atteints d'une sarcoïdose.
Mondobiotech Ag
Mondobiotech Laboratories Anstalt
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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