C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/575 (2006.01) A61K 38/22 (2006.01)
Patent
CA 2472270
The present invention relates to the use of peptides and pharmaceutical compositions containing said peptides, that are highly biologically and pharmacologically active as therapeutic drugs for the treatment of diseases related to chronic obstructive pulmonary disease (COPD) which is preferably not correlated to pulmonary hypertension symptoms. Furthermore, the invention discloses the use of said peptides for another lung disease which is acute (adult) respiratory distress syndrome (ARDS). It could be shown that the known naturally occurring peptides "vasoactive intestinal peptide (VIP)" and "pituitary adenylate cyclase-activating polypeptide (PACAP)" as well as analogues or derivatives of VIP and PACAP can be successfully used for the treatment of said diseases.
L'invention concerne l'utilisation de peptides et de compositions pharmaceutiques contenant lesdits peptides, d'une haute activité biologique et pharmacologique en tant que médicaments thérapeutiques pour le traitement d'affections apparentées à une broncho-pneumopathie chronique obstructive (COPD), de préférence non en corrélation avec des symptômes d'hypertension pulmonaire. L'invention concerne en outre l'utilisation desdits peptides pour une autre maladie pulmonaire, à savoir, le syndrome respiratoire aigu sévère (ARDS). On a montré que les peptides connus se présentant à l'état naturel <= peptides intestinaux vasoactifs (VIP) >= et <= polypeptides d'activation adénylate cyclase pituitaires (PACAP) >=, ainsi que des analogues ou des dérivés de VIP et de PACAP pouvaient être utilisés avec succès pour le traitement des maladies précitées.
Bevec Dorian
Mondobiotech Laboratories Anstalt
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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