Use of compounds which inhibit phosphatidic acid formation...

Details Use of compounds which inhibit phosphatidic acid formation... Use of compounds which inhibit phosphatidic acid formation...

A - Human Necessities

61

K

A61K 31/52 (2006.01) A61K 31/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2166324

The present invention was made as a result of discovering an entire new approach and therapeutic target of cancer therapy. In addition, a prototype inhibitor compound, 1-(11-dodecylamino-10-hydroxyundecyl)-3,7- dimethylxanthine, has been discovered that acts by inhibiting cellular accumulation of specific PA species and is an inhibitor of PC directed PLD.beta.. Accordingly, the present invention provides a method for treating and preventing the spread of cancers comprising treating a patient with a tumor with an effective amount of a compound that reduces cellular accumulation of PA4 species.

La méthode selon l'invention est le fruit de la découverte d'une approche et d'une cible thérapeutique entièrement nouvelles de la thérapie anti-cancéreuse. On a, de plus, découvert un composé inhibiteur prototype, la 1-(11-dodécylamino-10-hydroxyundécyl)-3,7-diméthylxanthine, qui agit en inhibant l'accumulation cellulaire d'espèces spécifiques d'acide phosphatidique (AP) et constitue un inhibiteur de la phospholipase D-.beta. dirigée par phosphatidylcholine (PC). L'invention concerne une méthode de traitement et de prévention du développement de cancers qui consiste à traiter un patient présentant une tumeur avec une dose efficace d'un composé réduisant l'accumulation cellulaire des espèces d'AP¿4?.

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