Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol...

Details Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol... Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol...

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/415 (2006.01) A61K 31/416 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2268314

The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) (see formula I) in which R1 to R4 have the meaning indicated in the description, as medicaments, and to new active compounds, in particular to their use as vasodilators, if appropriate in combination with organic nitrates and NO donors and if appropriate in combination with compounds which inhibit the degradation of cGMP.

La présente invention concerne la nouvelle application de 1-benzyl-3 condensés (hétaryl-substitués) de pyrazol, correspondant à la formule générale (I), où R<1> à R<4> ont la signification indiquée dans la description, en tant que médicaments et en tant que nouvelles substances actives, et notamment leur application en tant que vasodilatateurs, éventuellement combinés avec des nitrates organiques et des donneurs de NO, éventuellement combinés avec des composés qui inhibent la décomposition du GMP cyclique.

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