C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07K 16/00 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2347940
This invention provides compounds and methods for treating inflammation. The compounds modulate the core 2 oligosaccharide-mediated binding of inflammatory cells, such as neutrophils, to endothelial cells and other myeloid cells. Significantly, the of the invention methods block inflammation without affecting lymphocyte trafficking. In some embodiments, the compounds inhibit the activity of a core 2 GlcNAc transferase that is involved in synthesizing the core 2 oligosaccharides.
La présente invention concerne des composés et le traitement d'inflammation. Ces composés modulent la liaison induite par le 2 oligosaccharide du noyau des cellules inflammatoires, tels que les neutrophiles, avec les cellules endothéliales et autres cellules myéloïdes. Les procédés de cette invention bloquent l'inflammation de façon significative sans affecter le trafic des lymphocytes. Dans certains modes de réalisation, les composés inhibent l'activité d'une 2 GlcNAc transférase intervenant dans la synthèse des 2 oligosaccharides des noyaux.
Ellies Lesley G.
Marth Jamey D.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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