Use of cr1-binding molecules in clearance and induction of...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/28 (2006.01)

Patent

CA 2585849

The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effectiing clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which binds specifically to complement receptor 1 (CR1) and does not substantially bind to complement receptor 2 (CR2), linked to a second moiety which comprises the antigen or binds to the antigen. Methods of producing such molecules and their therapeutic and/or prophylactic uses are also featured.

La présente invention concerne des méthodes et des compositions associées à la découverte de molécules capables, à la fois, d'induire une réponse immunitaire à un antigène chez un mammifère et d'effectuer la clairance de cet antigène, avec de telles molécules qui renferment un premier groupe caractéristique présentant une partie de liaison à l'antigène qui se lie spécifiquement au récepteur du complément 1 (CR1) et qui ne se lie pratiquement pas au récepteur du complément 2 (CR2), lié à un second groupe caractéristique renfermant l'antigène ou se liant à l'antigène. Cette invention a également pour objet des méthodes de production de telles molécules et leur utilisation thérapeutique et/ou prophylactique.

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