Use of creatine analogues for the treatment of disorders of...

Details Use of creatine analogues for the treatment of disorders of... Use of creatine analogues for the treatment of disorders of...

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/198 (2006.01) A61K 31/395 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/41 (2006.01) A61K 31/4168 (2006.01) A61K 31/4172 (2006.01) A61K 31/505 (2006.01) A61K 31/64 (2006.01) A61K 38/28 (2006.01) C12Q 1/50 (2006.01)

Patent

CA 2231632

The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include: (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter, (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group; (5) compounds which modify the association of creatine kinase with other cellular components.

Utilisation de composés de créatine incluant de la cyclocréatine et du phosphate de créatine pour le traitement ou la prévention d'un désordre du métabolisme tel que l'hyperglycémie, le diabète sucré insulino-dépendant, l'altération de la tolérance du glucose, l'hyperinsulinémie, l'insensibilité à l'insuline, les maladies liées au diabète chez le patient souffrant de ce type de désordres. Les composés de créatine pouvant être utilisés dans le cadre de cette méthode sont 1) des analogues de créatine pouvant agir comme substrats ou comme analogues de substrats de créatine kinase; 2) des composés pouvant agir comme activateurs ou inhibiteurs de créatine kinase; 3) des composés qui peuvent moduler le transporteur de créatine; 4) des analogues de N-phosphocréatine portant des fractions transférables ou non qui imitent le groupe N-phosphoryle; 5) des composés qui modifient l'association de créatine kinase à d'autres composants cellulaires.

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