Use of creatine for the amelioration of oxidative stress

Details Use of creatine for the amelioration of oxidative stress Use of creatine for the amelioration of oxidative stress

A - Human Necessities

61

K

A61K 31/198 (2006.01) A61P 21/00 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2442112

The present invention relates to a method of amelioring oxidative stress and stress-related degenerative processes associated with aging or various disease conditions such as cancer, neurodegenerative diseases or the dysregulation of redox-regulated physiological processes, as indicated by the prooxidative shift in the plasma thil/disulfide redox state and its consequences in conditions of elevated oxidative stress, characterized by administering creatine.

L'invention concerne un procédé, caractérisé par l'administration de créatine, permettant d'atténuer l'agression oxydative et les processus de dégénérescence liés à cette agression, qui surviennent avec le vieillissement ou différentes maladies comme le cancer, les maladies neurodégénératives ou encore le dysfonctionnement des processus physiologiques régulés par l'oxydo-réduction. On intervient lorsque se manifeste un déséquilibre pro-oxydatif de l'état d'oxydo-réduction thiol/disulfure dans le plasma - ce déséquilibre entraînant une augmentation de l'agression oxydative.

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