Use of cross-linked, covalently bound urokinase plasminogen...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 38/49 (2006.01) A61P 7/02 (2006.01) C07K 1/10 (2006.01) C07K 14/705 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2453285

The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic activity and use of the cross-linked scuPA/suPAR or tcuPA/suPAR complex in the prevention and/or treatment of thrombolytic disorders. The invention further relates to combination compositions and/or therapy regimens, comprising the cross-linked scuPA/suPAR complex or tcuPA/suPAR and one or more currently used plasminogen activators to achieve improved therapeutic efficacy and/or reduce side effects.

L'invention porte sur le complexe réticulé scuPA/suPAR et/ou le complexe réticulé tcuPA/suPAR, sur le procédé de préparation du composé isolé lié par covalence et possédant une activité fibrinolytique et sur l'utilisation du composé réticulé scuPA/suPAR ou tcu/suPAR dans la prévention et/ou le traitement des troubles thrombolytiques. Cette invention se rapporte également à des compositions combinées et/ou à des régimes posologiques thérapeutiques contenant le complexe réticulé scuPA/suPAR ou tcuPA/suPAR et un ou plusieurs activateurs plasminogènes couramment utilisés afin d'obtenir une meilleure efficacité thérapeutique et/ou réduire les effets secondaires.

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