A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/40 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2231687
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen- mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorotioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
Procédé de réduction des effets immunostimulateurs de certains oligonucléotides comportant phosphorothioate, utilisés pour traiter des états pathologiques induits par des agents pathogènes et d'autres maladies. Selon le procédé de la présente invention, on réduit les effets immunostimulateurs des oligonucléotides comportant phosphorothioate en administrant lesdits oligonucléotides dans une composition pharmaceutique qui contient au moins une cyclodextrine à un mammifère atteint de la maladie ou de l'état pathologique traités. La présente invention concerne également la surveillance de la réponse immunitaire dudit mammifère.
Agrawal Sudhir
Temsamani Jamal
Zhao Qiuyan
Hybridon Inc.
Mbm & Co.
LandOfFree
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