Use of cyclohexane polycarboxylic acids as plasticizers in...

C - Chemistry – Metallurgy – 08 – K

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C08K 5/12 (2006.01) C07C 61/08 (2006.01) C07C 61/09 (2006.01) C08K 5/092 (2006.01)

Patent

CA 2376742

The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate.

La présente invention concerne l'utilisation d'un acide cyclohexanepolycarboxylique ou d'un dérivé de celui-ci, ou bien d'un mélange d'au moins deux de tels acides, comme plastifiant pour la production de matières plastiques dont la valorisation est favorable sur le plan toxicologique. L'expérimentation animale réalisée avec des rongeurs auxquels on a administré une dose orale journalière de 1000 mg par kg de poids du corps dudit acide cyclohexanepolycarboxylique ou dudit dérivé de celui-ci ou dudit mélange d'au moins deux de tels acides, au moyen d'une sonde oesophagique, pendant au moins quatorze jours, a montré que lesdits rongeurs, après leur traitement, en comparaison avec des animaux témoins non traités, ne présentant ni une augmentation significative du poids de leur foie, ni un doublement de l'activité spécifique de la palmitoyl-CoA oxydase insensible aux cyanures, activité mesurée dans l'homogénéisat du foie.

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