A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A01K 67/027 (2006.01) A61K 31/7048 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 16/46 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2423413
The present invention relates to methods of inhibiting uterine leiomyoma proliferation and preventing formation of uterine leiomyomas, compounds and compositions that stimulate induction of the Cyr61 gene and compounds that increase Cyr61 activity. The present invention also relates to methods of screening ligands that regulate Cyr61 protein expression. The invention further relates to methods of diagnosing patients with uterine leiomyomas associated with a downregulation of Cyr61 expression. The invention also describes antibodies and related pharmaceutical compositions.
Cette invention porte sur des procédés visant à inhiber la prolifération et la formation des léiomyomes utérins, sur des composés et des compositions qui stimulent l'induction du gène Cyr61 et sur des composés qui augmentent l'activité de Cyr61. Cette invention porte également sur des procédés de criblage des ligands qui régulent l'expression de la protéine Cyr61, ainsi que sur des procédés de diagnostic de patientes souffrant de léiomyomes utérins associés à une régulation négative de l'expression de Cyr61. L'invention porte en outre sur des anticorps et des compositions pharmaceutiques apparentées.
Sampath Deepak
Winneker Richard
Zhang Zhiming
Zhu Yuan
Ridout & Maybee Llp
Wyeth
LandOfFree
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