Use of cytidine-, creatine-, and adenosine-containing...

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01)

Patent

CA 2508995

The invention provides methods for normalizing the sleep/wake cycle of a mammal by administering a therapeutically-effective amount of a cytosinecontaining or cytidine-containing compound, uridine-containing compound, creatine-containing compound, adenosine-containing, or adenosine- elevating compound. As such the methods described herein may increase wakefulness, reduce tiredness or fatigue during the day, and improve sleep quality. The methods of the invention may also be used in the treatment of sleep disorders, such as insomnia, sleep apnea, periodic limb movements, restless leg syndrome, narcolepsy, and problem sleepiness, or for increasing cognitive function in sleep deprived individuals. Citicoline is an exemplary compound for use in the methods described herein.

La présente invention a trait à des procédés permettant la normalisation du cycle sommeil/état de veille d'un mammifère par l'administration d'une quantité thérapeutiquement efficace d'un composé contenant de la cytosine ou de la cytidine, un composé contenant de l'uridine, un composé contenant de la créatine, un composé contenant de l'adénosine, ou d'activation de l'adénosine. Les procédés de l'invention peuvent accroître l'état de veille, réduire la fatigue, et améliorer la qualité du sommeil. Les procédés de l'invention peuvent également être utilisés dans le traitement de troubles du sommeil, tels que l'insomnie, l'apnée du sommeil, les mouvements involontaires des membres, le syndrome des jambes sans repos, la narcolepsie, la somnolence due aux problèmes, ou pour accroître la fonction cognitive dans des individus privés de sommeil. La citicoline est un exemple de composé pouvant être utilisé dans les procédés de l'invention.

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