Use of cytoskeletal inhibitors for the prevention of restenosis

Details Use of cytoskeletal inhibitors for the prevention of restenosis Use of cytoskeletal inhibitors for the prevention of restenosis

A - Human Necessities

61

K

A61K 31/4035 (2006.01) A61K 9/00 (2006.01) A61K 31/337 (2006.01) A61L 27/54 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2285389

Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.

L'invention porte sur des procédés d'inhibition de la sténose ou resténose après un traumatisme vasculaire d'un hôte mammalien, ces procédés consistant à administrer à l'hôte un dosage thérapeutiquement efficace d'un agent cytostatique et/ou d'un inhibiteur de cytosquelette de manière à étirer biologiquement le vaisseau atteint. L'invention porte également sur un procédé d'inhibition ou de réduction du remodelage vasculaire, procédé consistant à administrer une quantité efficace d'un inhibiteur de cytosquelette. L'invention porte en outre sur des compositions pharmaceutiques et des kits comprenant les agents thérapeutiques de l'invention.

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