Use of dapsone as neuroprotector in the brain stroke

Details Use of dapsone as neuroprotector in the brain stroke Use of dapsone as neuroprotector in the brain stroke

A - Human Necessities

61

K

A61K 31/145 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2533181

The invention relates to the use of dapsone as the first effective treatment against the disabling consequences associated with cerebral infarction in patients. Dapsone was evaluated as a neuroprotector in the cerebral infarction model produced by the occlusion of the middle cerebral artery in rats and in patients suffering from acute cerebral infarction caused by thromboembolism. In both studies, dapsone displayed a reduction of between 70 and 90 % in the adverse effects which occur as a consequence of the infarction.

La présente invention concerne l'utilisation de la dapsone dans le traitement des conséquences invalidantes associées à l'infarctus cérébral chez les patients affectés. La dapsone est définie comme un neuroprotecteur dans le modèle d'infarctus cérébral causé par l'occlusion de l'artère cérébrale moyenne chez des rats et des patients ayant souffert d'un infarctus cérébral aigu par thromboembolie. Dans les deux cas, la dapsone permet de réduire de 70 à 90 % des conséquences invalidantes de l'accident ischémique cérébral.

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