Use of defibrotide for the inhibition of heparanase

Details Use of defibrotide for the inhibition of heparanase Use of defibrotide for the inhibition of heparanase

A - Human Necessities

61

K

A61K 31/711 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2655522

A study has been carried out to verify the effect of Defibrotide on the activity and expression of Heparanase enzyme on myeloma tumor cells (U266) and human microvascular endothelial cells (HMEC). The study has demonstrated that defibrotide can be effectively used for the manufacture of a medicament for the treatment of diseaseses which are positively affected by the inhibition of Heparanse and/or by the downregulation of Heparanse gene expression, such as diabetes.

Selon l'invention, une étude a été réalisée pour vérifier l'effet du défibrotide sur l'activité et l'expression d'une enzyme, l'héparanase, dans des cellules de myélome (U266) et des cellules épithéliales de capillaires humains (Human Microvascular Endothelial Cells; HMEC). L'étude a démontré que le défibrotide peut être utilisé efficacement pour la fabrication d'un médicament destiné au traitement de maladies, le diabète par exemple, dans lesquelles un effet positif est obtenu par l'inhibition de l'héparanase et/ou par la régulation négative de l'expression du gène de l'héparanase.

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