A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/568 (2006.01) A61K 31/33 (2006.01) A61K 31/56 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2310632
Lupus erythematosus can be treated by administering therapeutic amounts of .DELTA.5-androstene-3.beta.-ol-7,17-dione and metabolizable precursors thereof, such as .DELTA.5-androstene-3b-acetoxy-7,17-dione, which are readily metabolized in vivo to .DELTA.5-androstene-3.beta.-ol-7,17-dione but are not appreciably metabolizable in vivo to androgens, estrogens or dehydroepiandrosterone. Such treatment can be prophylactic, ameliorative or curative in nature.
Selon cette invention, il est possible de traiter le lupus érythémateux en administrant des quantités thérapeutiques de .DELTA.5-androstène-3.beta.-ol-7,17-dione et ses précurseurs métabolisables tels que .DELTA.5-androstène-3b-acétoxy-7,17-dione qui sont facilement métabolisés in vivo en .DELTA.5-androstène-3b-acétoxy-7,17-dione, mais ne peuvent pas être métabolisés in vivo en androgènes, oestrogènes ou déhydroépiandrostérone. Ce traitement peut être de nature prophylactique, thérapeutique ou curative.
Lardy Henry A.
Weeks Charles E.
Humanetics Corporation
Sim & Mcburney
LandOfFree
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