Use of derivatives of 2, 4-dihydro-[1,2,4]triazole-3-thione...

Details Use of derivatives of 2, 4-dihydro-[1,2,4]triazole-3-thione... Use of derivatives of 2, 4-dihydro-[1,2,4]triazole-3-thione...

C - Chemistry, Metallurgy

07

D

C07D 249/12 (2006.01) A61K 31/4196 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2523020

There is disclosed the use of a compound of formula (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

L'invention concerne l'utilisation d'un composé de la formule (I) où X, Y, W et Q ont la signification donnée dans la description, et de leurs sels pharmaceutiquement acceptables pour produire un médicament destiné au traitement ou à la prévention de maladies ou d'états dans lesquels l'inhibition de l'enzyme myélopéroxydase (MPO) est bénéfique. L'invention concerne certains nouveaux composés de la formule (I) et leurs sels pharmaceutiquement acceptables ainsi que leurs procédés de préparation. Les composés de la formule (I) sont des inhibiteurs de la MPO et sont donc particulièrement utiles dans le traitement ou la prévention de troubles neuro-inflammatoires.

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