Use of derivatives of valproic acid and 2-valproenic acid...

A - Human Necessities – 61 – K

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A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2416821

A method for the treatment of mania in bipolar disorder using derivatives of valproic acid and 2-valproenic acid amines having the following structures: wherein R1, R2, and R3 are independently the same or different and are hydrogen, a C1-C6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal 3, or a compound containing a valproic or a 2-valproenic moiety, as well as pharmaceutical compositions comprising these derivatives or compounds.

L'invention concerne un procédé de traitement de la manie en cas de désordre bipolaire, selon lequel on utilise des dérivés d'acide valproïque et des amides d'acide 2-valproénique présentant les structures (I) ou (II), ou bien un composé contenant une fraction valproïque ou 2-valproénique, ainsi que des compositions pharmaceutiques contenant ces dérivés ou composés. Dans lesdites structures, R¿1?, R¿2? et R¿3? sont identiques ou différents et représentent indépendamment l'un de l'autre hydrogène, ou un groupe aryle, et n représente un nombre entier qui est supérieur ou égal à 0 et inférieur ou égal à 3.

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