Use of desloratadine for treating allergic and inflammatory...

A - Human Necessities – 61 – K

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A61K 31/4545 (2006.01) A61P 11/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2398264

The use of desloratadine for the preparation of a medicament for the treatment and/or prevention of allergic and inflammatory conditions of the skin or airway passages in a human of 12 years and older in need of such treatment and/or prevention by administration of an amount of desloratadine, e.g., 5mg/day for 10 days, sufficient to produce a geometric mean steady state maximum plasma concentration of desloratadine in the range of 2.90 ng/mL to 4.54 ng/mL, preferably 3.63 ng/mL, or an arithmetic mean steady state maximum plasma concentration of desloratadine in the range of 3.2 ng/mL to 5.0 ng/mL, preferably 4ng/mL .

Selon l'invention, l'utilisation de désloratadine pour la préparation d'un médicament destiné au traitement et/ou à la prévention de troubles allergiques et inflammatoires de la peau ou des voies respiratoires chez un humain d'au moins 12 ans, nécessitant ce traitement et/ou cette prévention, par administration d'une quantité de désloratadine, par exemple, 5mg/jour pendant 10 jours, est suffisante pour produire une concentration plasmatique en moyenne géométrique, maximale et continue, de désloratadine comprise entre 2,90 ng/mL et 4,54 ng/mL, de préférence de 3,63 ng/mL, ou une concentration plasmatique, en moyenne arithmétique, maximale et continue, comprise entre 3,2 ng/mL et 5,0 ng/mL, de préférence de 4ng/mL.

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