A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/721 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2507595
The present invention refers to use of dextran sulfate, or a pharmaceutically acceptable derivate thereof, for manufacturing of a medicament for treatment of Instant Blood-Mediated Inflammatory Reaction (IBMIR). In addition, the invention refers to the use of dextran sulfate, or a pharmaceutically acceptable derivate thereof, for manufacturing of a medicament for treatment of morphological disruption of cell transplants and graft-rejection of cell transplants caused by IBMIR. The invention may be applied to patients suffering from type I diabetes, in which porcine islets of Langerhans are transplanted in their portal vein. Administration of dextran sulfate according to the invention inhibits and prevents rejection and destruction of the transplanted islets and makes normoglycemia in the patients possible.
La présente invention se rapporte à l'utilisation du dextran-sulfate, ou d'un dérivé pharmaceutiquement acceptable de ce dernier, pour produire un médicament destiné à traiter la réaction inflammatoire sanguine instantanée (IBMIR). De plus, l'invention concerne l'utilisation du dextran-sulfate, ou d'un dérivé pharmaceutiquement acceptable de ce dernier, pour produire un médicament destiné à traiter l'altération morphologique de greffons cellulaires et le rejet de greffons cellulaires causés par l'IBMIR. L'invention peut servir à des patients atteints d'un diabète de type I, dans la veine porte desquels des îlots de Langerhans porcins sont transplantés. L'administration du dextran-sulfate selon l'invention permet d'inhiber et de prévenir le rejet et la destruction des îlots transplantés, et permet d'obtenir la normoglycémie chez les patients.
Korsgren Olle
Nilsson Bo
Freedman & Associates
Prophymed Ab
Tx Medic Ab
LandOfFree
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