Use of diindolylmethane-related indoles for the treatment...

A - Human Necessities – 61 – K

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A61K 31/405 (2006.01)

Patent

CA 2593084

The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include acute infections in mammals, typically bronchiolitis and pneumonia, and post-infectious chronic respiratory conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3'-~diindolylmethane (DIM), or a DIM-related indole, alone or in combination with an inhibitor of a membrane bound Epidermal Growth Factor Receptor (EGFR) inhibitors, to treat conditions associated with exposure to RSV.

La présente invention porte sur des compositions et sur des méthodes de traitement et de prévention d'états associés à l'infection par le virus respiratoire syncytial (RS). Les états associés au virus respiratoire syncytial sont des infections aiguës affectant des mammifères, généralement la bronchiolite et la pneumonie, et des états respiratoires chroniques post-infectieux. La présente invention porte notamment sur de nouvelles utilisations thérapeutiques et préventives de 3,3'--diindolylméthane (DIM), ou d'un indole lié à DIM, seul ou en combinaison avec un inhibiteur du récepteur du facteur de croissance épidermique (RFCE) fusionné à la membrane, des inhibiteurs pour traiter des états associés à l'exposition au virus respiratoire syncytial.

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