Use of dillapiol and its analogues and derivatives to affect...

A - Human Necessities – 61 – K

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A61K 31/36 (2006.01) A01N 43/30 (2006.01) A01N 43/90 (2006.01) A61K 31/357 (2006.01)

Patent

CA 2198645

The method of this invention entails the use of dillapiol or its analogues and derivatives to affect cells expressing multidrug resistance (MDR) activity. In one aspect, dillapiol or its analogues and derivatives are used alone as agents that exert a direct toxic effect on cells presenting an MDR phenotype. In another aspect, dillapiol or its analogues and derivatives are used as chemosensitizers to chemical agents, such as chemotherapeutic agents, insecticides, and nicotine, in order to increase the efficacy of these agents. This method is useful for treating pathologies and physiologies in which MDR plays a role, such as certain cancers and diseases (eg. malaria), different states of tolerance or resistance (eg to insecticides), and addiction (eg. to nicotine and opiates).

La méthode couverte par cette invention a trait à l'usage du dillapiol ou de ses analogues et dérivés pour agir sur les cellules exprimant une résistance à de nombreux médicaments (multirésistance). Dans une matérialisation, le dillapiol ou ses analogues et dérivés sont utilisés seuls comme agents exerçant un effet toxique direct sur les cellules qui présentent un phénotype de multirésistance. Dans une autre, le dillapiol ou ses analogues et dérivés sont utilisés comme chimiosensibilisants à certains agents chimiques, comme les agents chimiothérapeutiques, les insecticides et la nicotine, afin d'accroître l'efficacité de ces agents. Cette méthode est utile pour le traitement des pathologies ainsi que des processus physiologiques dans lesquels intervient la multirésistance aux médicaments, comme certains cancers ou maladies (p. ex. le paludisme), différents états de tolérance ou de résistance (p. ex. aux insecticides), et la dépendance (vis-à-vis de la nicotine et des opiacés).

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