Use of dinucleoside polyphosphate to stimulate removal of...

A - Human Necessities – 61 – K

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A61K 31/7084 (2006.01) A61K 31/70 (2006.01) A61P 27/02 (2006.01) C07H 19/04 (2006.01) C07H 19/20 (2006.01) C07H 19/207 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2436429

The present invention provides a method of treating edematous retinal disorders. The method comprised administration of a pharmaceutical composition comprising a P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from the subretinal and retinal spaces and thereby reduce the accumulation of said fluid associated with retinal detachment and retinal edema. The P2Y receptor agonist may be administered with therapeutic and adjuvant agents commonly used to treat edematous retinal disorders. The pharmaceutical compostion useful in this invention comprises a P2Y receptor agonist with enhanced resistance to extracellular hydrolysis, such as dinucleoside polyphosphate compounds.

La présente invention concerne une méthode de traitement de troubles rétiniens oedémateux. Ladite méthode consiste à administrer une composition pharmaceutique comprenant un agoniste récepteur P2Y de manière à stimuler l'élimination du fluide étranger pathologique provenant des espaces rétiniens et sous-rétiniens, et donc à diminuer l'accumulation dudit fluide lié au détachement et à l'oedème de la rétine. On peut administrer l'agoniste récepteur P2Y avec des agents thérapeutiques et adjuvants utilisés généralement pour traiter des troubles rétiniens oedémateux. La composition pharmaceutique utilisée dans cette invention contient un agoniste récepteur P2Y doté d'une résistance améliorée à l'hydrolyse extracellulaire, telle que des composés de dinucléoside polyphosphate.

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