Use of disease-associated gene

Details Use of disease-associated gene Use of disease-associated gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61P 11/06 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2392472

An antisense DNA to a disease-associated gene; drugs containing this antisense DNA; an antibody against a disease-associated gene product; diagnostics containing this antibody; a method of screening a compound inhibiting the activity of the disease-associated gene product; compounds obtained by this screening method, etc.A compound which inhibits the activity of a protein having an amino acid identical or substantially identical with the amino acid sequence represented by SEQ ID NO:1 or its salt and a neutralizing antibody inhibiting the activity of the protein are usable as, for example, preventives and remedies for bronchial asthma, chronic obstructive pulmonary disease, etc. The antisense DNA can inhibit the expression of a protein having an amino acid identical or substantially identical with the amino acid sequence represented by SEQ ID NO:1 and is usable as, for example, preventives and remedies for bronchial asthma, chronic obstructive pulmonary disease, etc.

L'invention concerne de l'ADN antisens relatif à un gène associé à une maladie; des médicaments renfermant cet ADN; un anticorps vis-à-vis d'un produit génique associé à une maladie; des produits diagnostiques renfermant l'anticorps en question; un procédé de criblage de composé inhibant l'activité du produit génique susmentionné; des composés résultant de l'utilisation du procédé de criblage, etc. Un composé inhibant l'activité d'une protéine ayant un acide aminé identique ou sensiblement identique à la séquence d'acides aminés SEQ ID NO:1 ou un sel correspondant et un anticorps de neutralisation inhibant l'activité de la protéine sont utilisables, par exemple, afin de prévenir et de traiter l'asthme, la bronchopneumopathie chronique obstructive, etc. L'ADN antisens peut inhiber l'expression d'une protéine ayant un acide aminé identique ou sensiblement identique à la séquence d'acides aminés SEQ ID NO:1, et on peut l'utiliser, par exemple, afin de prévenir et de traiter l'asthme, la bronchopneumopathie chronique obstructive, etc.

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