Use of double-stranded ribonucleic acid for inducing cell lysis

A - Human Necessities – 61 – K

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A61K 31/713 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2530125

The present invention is related to the use of a ribonucleic acid for the manufacture of a medicament, whereby the ribonucleic acid comprises a double- stranded structure and the double-stranded structure comprises a first and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and the second strand comprises a second stretch of contiguous nucleotides, whereby the first stretch is not complementary to a nucleic acid, preferably a mRNA, of a cell of an organism to be treated with said medicament and/or whereby the second stretch is different from a nucleic acid, preferably a mRNA of a cell of an organism to be treated with said medicament.

La présente invention concerne l'utilisation d'un acide ribonucléique pour la fabrication d'un médicament. Cet acide nucléique comprend une structure à double brin, et cette structure comprend un premier et un second brin. Le premier brin comprend une première suite de nucléotides contigus et le second brin une seconde suite de nucléotides contigus. Le premier brin n'est pas complémentaire d'un acide nucléique, de préférence ARNm, d'une cellule de l'organisme à traiter et/ou le second brin est différent d'un acide nucléique, de préférence un ARNm, d'une cellule d'un organisme à traiter au moyen dudit médicament.

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