C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07K 16/46 (2006.01) C12N 15/113 (2010.01) C07K 14/705 (2006.01)
Patent
CA 2744043
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating apoptosis in cells of the nervous system. In addition, it has been discovered that p75 is a ligand for DR6. As a result, this invention relates to methods for inhibiting the interaction of DR6 and p75 using DR6 and/or p75 antagonists. In addition, the methods described herein include methods of promoting survival of cells of the nervous system using DR6 antagonists, optionally in combination with p75 antagonists, and methods of treating neurodegenerative conditions by the administration of a DR6 antagonists, optionally in combination with a p75 antagonist.
L'invention concerne les protéines du récepteur de mort-6 (DR6) qui sont des éléments de la famille du récepteur du facteur de nécrose tumorale (TNF) et qui se révèlent aujourd'hui importants pour réguler l'apoptose dans des cellules du système nerveux. De plus, p75 est un ligand pour DR6. L'invention concerne donc des procédés permettant d'inhiber l'interaction de DR6 et de p75 au moyen des antagonistes DR6 et/ou p75. En outre, les procédés selon l'invention comportent des procédés qui favorisent la survie de cellules du système nerveux au moyen des antagonistes DR6, éventuellement en combinaison avec un antagoniste p75.
Mi Sha
Pepinsky R. Blake
Rhodes Kenneth J.
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
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