A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/13 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2542419
The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of diseases that can be treated by modulation of QC-activity, e.g. diseases selected from the group consisting of duodenal cancer with or w/o Heliobacter pylori infections, colorectal cancer, Zolliger-Ellison syndrome, Familial British Dementia and Familial Danish Dementia.
La présente invention concerne de nouveaux substrats physiologiques de la cyclase de glutaminyle des mammifères (QC, EC 2.3.2.5), de nouveaux effecteurs de ces cyclases, et l'utilisation de ces effecteurs et de compositions pharmaceutiques à base de tels effecteurs pour traiter des affections admettant un traitement par modulation de l'activité de cyclase de glutaminyle. Ces affections sont essentiellement des maladies appartenant au groupe du cancer duodénal avec ou sans infection par Helicobacter pylori, du cancer colorectal, du syndrome de Zolliger-Ellison, de la démence familiale britannique et de la démence familiale danoise.
Demuth Hans-Ulrich
Heiser Ulrich
Hoffmann Torsten
Niestroj Andre Johannes
Schilling Stephan
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Probiodrug Ag
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