Use of egf-r protein tyrosine kinase inhibitors for...

Details Use of egf-r protein tyrosine kinase inhibitors for... Use of egf-r protein tyrosine kinase inhibitors for...

A - Human Necessities

61

K

A61K 31/353 (2006.01) A61K 8/49 (2006.01) A61K 31/352 (2006.01) A61Q 17/04 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2414406

Photoaging of human skin, such as evidenced by the increased presence of matrix metalloproteinases after exposure to UV radiation, is prevented by pre- treating the skin with an inhibitor of epideremal growth factor receptor (EGF- R) prior to exposure. Such inhibitors are preferably natural, an example of which is geniestein. Compositions used for such purposes preferably include an EGF-R inhibitor as well as another MMP inhibitor, such as a retinoid.

L'invention concerne le photovieillissement de la peau humaine, signalé entre autres par l'augmentation de la présence de métalloprotéinases matricielles après une exposition aux rayonnements ultraviolets. On prévient ce phénomène par un traitement préalable de la peau avec un inhibiteur de l'EGF-R, avant l'exposition. De préférence, ce type d'inhibiteur est naturel (par exemple, génistéine). Les compositions utilisées à cette fin comprennent de préférence un inhibiteur d'EGF-R et un autre inhibiteur de métalloprotéinases matricielles, du type rétinoïde.

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