A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01)
Patent
CA 2397733
A method of treating pulmonary hypertension in a subject in need of such treatment comprises inhibiting EMAP II activity in the subject by an amount effective to treat the pulmonary hypertension in the subject (e.g., in the lungs and more particularly in the pulmonary vasculature). Pharmaceutical formulations useful for carrying out such methods (e.g., an antibody that specifically binds to EMAP II in a pharmaceutically acceptable carrier) and screening techniques useful for identifying additional compounds that can be used for carrying out such methods are also disclosed.
L'invention concerne une méthode de traitement de l'hypertension pulmonaire chez un sujet nécessitant un tel traitement, consistant à inhiber l'activité d'EMAP II (polypeptide activant le monocyte endothélial), par administration audit sujet d'une dose efficace, afin de traiter l'hypertension pulmonaire (par exemple dans les poumons et en particulier dans le système vasculaire pulmonaire). L'invention concerne également des formulations pharmaceutiques utiles dans l'application de telles méthodes (par exemple un anticorps se liant de manière spécifique à EMAP II et placé dans un support acceptable sur le plan pharmacologique), ainsi que des techniques de criblage utiles pour identifier d'autres composés que l'on peut utiliser pour l'application desdites méthodes.
Children's Hospital Los Angeles
Sim & Mcburney
LandOfFree
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